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The goal of nutrition of the preterm infant is to meet the growth rate of the healthy fetus of the same gestational age and to produce the same body composition of the healthy fetus in terms of organ growth, tissue components, and cell number and structure. Nutritional quantity and quality are fundamental for normal growth and development of preterm infants, including neurodevelopmental outcomes. Failure to provide the necessary amounts of all of the essential nutrients has produced not only growth failure, but also increased morbidity and less than optimal neurodevelopment. Growth velocities during the NICU hospitalization period for preterm infants exert a significant effect on neurodevelopmental and anthropometric outcomes. Despite the obvious need for optimal nutrition, growth failure is almost universal among preterm infants. There is every reason, therefore, to optimize nutrition of the preterm infant, in terms of total energy and protein, but also in terms of individual components such as amino acids, specific carbohydrates and lipids, and even oxygen. This review presents scientific rationale for nutrient requirements and practical guidelines and approaches to intravenous and enteral feeding for preterm infants. Intravenous feeding, including amino acids, should be started right after birth at rates that are appropriate for the gestational age of the infant. Enteral feeding should be started as soon as possible after birth, using mother's colostrum and milk as first choices. Enteral feeding should begin with trophic amounts and advanced as rapidly as tolerated, decreasing IV nutrition accordingly, while maintaining nutrient intakes at recommended rates. Feeding protocols are valuable for improving nutrition and related outcomes. Further research is needed to determine the optimal nutrition and rate of growth in preterm infants that will achieve optimal neurocognitive benefits while minimizing the longer-Term risk of chronic diseases.
Preterm birth survivors are at a higher risk of growth and developmental disabilities compared to their term counterparts. Development of strategies to lower the complications of preterm birth forms the rising need of the hour. Appropriate nutrition is essential for the growth and development of preterm infants. Early administration of optimal nutrition to preterm birth survivors lowers the risk of adverse health outcomes and improves cognition in adulthood. A group of neonatologists, pediatricians, and nutrition experts convened to discuss and frame evidence-based recommendations for optimizing nutrition in preterm low birth weight (LBW) infants. The following were the primary recommendations of the panel: (1) enteral feeding is safe and may be preferred to parenteral nutrition due to the complications associated with the latter; however, parenteral nutrition may be a useful adjunct to enteral feeding in some critical cases; (2) early, fast, or continuous enteral feeding yields better outcomes compared to late, slow, or intermittent feeding, respectively; (3) routine use of nasogastric tubes is not advisable; (4) preterm infants can be fed while on ventilator or continuous positive airway pressure; (5) routine evaluation of gastric residuals and abdominal girth should be avoided; (6) expressed breast milk (EBM) is the first choice for feeding preterm infants due to its beneficial effects on cardiovascular, neurological, bone health, and growth outcomes; the second choice is donor pasteurized human milk; (7) EBM or donor milk may be fortified with human milk fortifiers, without increasing the osmolality of the milk, to meet the high protein requirements of preterm infants; (8) standard fortification is effective and safe but does not fulfill the high protein needs; (9) use of targeted and adjustable fortification, where possible, helps provide optimal nutrition; (10) optimizing weight gain in preterm infants prevents long-term cardiovascular complications; (11) checking for optimal weight and sucking/swallowing ability is essential prior to discharge of preterm infants; and (12) appropriate counseling and regular follow-up and monitoring after discharge will help achieve better long-term health outcomes. This consensus summary serves as a useful guide to clinicians in addressing the challenges and providing optimal nutrition to preterm LBW infants. KEYWORDS: donor pasteurized human milk; enteral feeding; expressed breast milk; fortification; optimizing nutrition; preterm low birth weight infants
Continuation rates of postpartum intrauterine contraceptive device (IUCD) insertion: randomised trial of post placental versus immediate postpartum insertion. Introduction The postpartum period is a critical period with special needs for both mother and neonate. The unmet need of long acting contraception to space pregnancy in the postpartum period can be fulfilled by postpartum intrauterine contraceptive device (IUCD) insertion. This study was undertaken to compare the continuation and complication rates of postpartum CuT 380 A insertion in postplacental and immediate (<48 hours) postpartum period after vaginal delivery. Methods This randomised controlled trial with ethical clearance from institutional ethics committee was done in the Obstetrics and Gynecology Department, Lok Nayak Jaiprakash Hospital, New Delhi where 263 vaginally delivered women meeting the eligibility criteria as laid by Ministry of Health and Family Welfare, Government of India, willing for postpartum IUCD insertion were randomised to two groups- Group A (postplacental i.e. within 10 min of placental expulsion n = 131) and Group B (immediate postpartum i.e. 10 min-48 hours postdelivery n = 132) and followed-up upto 6 months. IUCD inserted was CuT 380 A using Kelly Placental Forceps curved or Sponge holder by trained health personal. Sample size calculation was done based on the mean incidence of expulsion in the two groups 11% in postplacental group versus 28% in immediate postpartum group with power of study 80% and confidence interval 95% was found to be 172 and with attrition rate of 25% the total size was calculated to be 215 with 108 in each group. The difference between means for quantitative data was calculated by Student 't' test and for qualitative data was computed using c-square/Fischer's exact test was used. P < 0.05 was the cut off point for statistical significance. Expulsion rates, continuation rates at 6 months, complications rate, removal rates for pain and bleeding, patients acceptability were compared in two groups. Results Continuation rates were 88.9% in postplacental group compared to 74.10% in immediate postpartum group (P = 0.0054). Expulsion rates were 24.11% in immediate postpartum group compared to 9.11 in postplacental group (P = 0.0037). Overall incidence of complications of PPIUCD was 6.7% including PID (1.3%) menorrhagia (3.1%) pain abdomen (0.83%) and prolonged lochia (1.3%) and the rates being similar in two groups however requiring removal in 2.17% women similar in each group. Conclusions Postpartum IUCD insertion is acceptable means of contraception and for women who accept postpartum IUCD insertion, postplacental insertion should be preferred over immediate postpartum insertion.