Calil VMLT, Palmeira P, Zheng Y, Krebs VLJ, Carvalho WB, Carneiro-Sampaio M. CoronaVac can induce the production of anti-SARS-CoV-2 IgA antibodies in human milk. Clinics (Sao Paulo). 2021 Jun 28;76:e3185. doi: 10.6061/clinics/2021/e3185. PMID: 34190859; PMCID: PMC8221553.
Human milk is the external secretion with the highest immunoglobulin A (IgA) concentrations, mostly produced in the lamina propria of mammary glands by plasma cells (1). The milk antibody repertoire is quite similar to the one observed in the blood; however, the levels of antibodies against enteric and respiratory pathogens are usually higher in the colostrum and mature milk than in the serum. Maternal immunization can elicit systemic immunoglobulin G (IgG) and mucosal IgA, IgM, and IgG responses that confer protection to the newborn infants.
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