Duration of Treatment for Asymptomatic Bacteriuria During Pregnancy

Widmer M, Gülmezoglu AM, Mignini L, Roganti A. Duration of treatment for asymptomatic bacteriuria during pregnancy. Cochrane Database Syst Rev. 2011 Dec 7;(12):CD000491. doi: 10.1002/14651858.CD000491.pub2. Review. Update in: Cochrane Database Syst Rev. 2015;11:CD000491. PubMed PMID: 22161364.

Background
A Cochrane systematic review has shown that drug treatment of asymptomatic bacteriuria in pregnant women substantially decreases the risk of pyelonephritis and reduces the risk of preterm delivery. However, it is not clear whether single‐dose therapy is as effective as longer conventional antibiotic treatment.

Objectives
To assess the effects of different durations of treatment for asymptomatic bacteriuria in pregnancy.

Search methods
We searched the Cochrane Pregnancy and Childbirth Group’s Trials Register (31 August 2011) and reference lists of identified articles.

Selection criteria
Randomized and quasi‐randomized trials comparing antimicrobial therapeutic regimens that differed in duration (particularly comparing single dose with longer duration regimens) in pregnant women diagnosed with asymptomatic bacteriuria.

Data collection and analysis
We assessed trial quality and extracted data independently.

Main results
We included 13 studies, involving 1622 women. All were comparisons of single‐dose treatment with four‐ to seven‐day treatments. The trials were generally of limited quality. The ‘no cure rate’ for asymptomatic bacteriuria in pregnant women was slightly higher for the single‐dose than for the short‐course treatment; however, these results were not statistically significant and showed heterogeneity. When comparing the trials that used the same antibiotic in both treatment and control groups with the trials that used different antibiotics in both groups, the ‘no cure rate’ risk ratio was similar. There was no statistically significant difference in the recurrence of asymptomatic bacteriuria rate between treatment and control groups. Slight differences were detected for preterm births and pyelonephritis although, apart from one trial, the sample size of the trials was inadequate. Single‐dose treatment was associated with a decrease in reports of ‘any side‐effects’ .

Authors’ conclusions
Single‐dose regimen of antibiotics may be less effective than the seven‐day regimen. Women with asymptomatic bacteriuria in pregnancy should be treated by the standard regimen of antibiotics until more data become available testing seven‐day compared with three‐ or five‐day regimens.

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