Mechanisms of perinatal brain injury

Artigo de acesso restrito

Terrie E. Inder, Joseph J. Volpe, Mechanisms of perinatal brain injury, Seminars in Neonatology, Volume 5, Issue 1, 2000, Pages 3-16, ISSN 1084-2756, https://doi.org/10.1053/siny.1999.0112. (http://www.sciencedirect.com/science/article/pii/S1084275699901124)

This article is focused on the mechanisms underlying primarily ischaemic/reperfusion brain injury in both the term and premature infant. Although the mechanisms involved include similar initiating events, principally ischaemia–reperfusion, and similar final common pathways to cell death, particularly free radical-mediated events, there are certain unique maturational factors influencing the type and pattern of cellular injury. We will therefore initially describe the physiological and cellular/molecular mechanisms of brain injury in the term infant, followed by the mechanisms in the premature infant.

Keywords: newborn, infant, prematurity, hypoxic–ischaemic injury, brain, periventricular leukomalacia, perinatal asphyxia, intraventricular haemorrhage

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