Therapeutic Hypothermia is Associated with Changes in Prognostic Value …

Ferrari F, Bedetti L, Cavalleri F, Lucaccioni L, Bertoncelli N, Guidotti I, Lugli L, Roversi MF, Della Casa Muttini E, Pugliese M, Arpi E, D’Amico R, Berardi A. Therapeutic hypothermia is associated with changes in prognostic value of general movements. Eur J Paediatr Neurol. 2023 Jan;42:53-59. doi: 10.1016/j.ejpn.2022.12.004. Epub 2022 Dec 16. PMID: 36563466.

Background and aims
General movements (GMs) have been recognized as the most accurate clinical tools for predicting cerebral palsy (CP). This study aimed to compare the type and prognostic value of abnormal GMs in infants with hypoxic ischemic encephalopathy treated or not with therapeutic hypothermia (TH).

Materials and methods
This was a single-center retrospective study. We compared GMs of 55 cooled term infants versus 30 non-cooled term infants with hypoxic ischemic encephalopathy (HIE) and their motor outcome at 24 months of age. We also included data regarding early brain MRI scans.

Results
Rates of cerebral palsy was 5.4% and 46.7% in cooled and non-cooled infants respectively (p < 0.001). None of cooled infants showed cramped-synchronized GMs, whereas among non-cooled infants the cramped-synchronized pattern was present in 17.2% and 20% of infants at 1 and 3 months of age respectively. Hypokinesis was never seen in cooled infants and it was present in 23.3% of non-cooled ones. Absent fidgety correlated with CP in 14% and 73% of cooled and non-cooled infants respectively. At brain MRI cooled infants had fewer and less severe cerebral lesions compared to non-cooled infants (p = 0.003).

Conclusions
Abnormal GMs are reduced in infants treated with TH. Hypokinesis and cramped-synchronized GMs are not observed in cooled infants and the associations between absent fidgety movements and CP it is largely abolished. TH is associated with changes in prognostic value of GMs.

Keywords
Brain MRI; Cerebral palsy; General movements; Hypoxic ischemic encephalopathy; Neurodevelopmental follow-up; Therapeutic hypothermia.

Disponível Em: <https://pubmed.ncbi.nlm.nih.gov/>